The CTSI Participant and Clinical Interactions (PCI) Core promotes protocol innovation, quality, and efficiency across the research study life cycle, from conceptualization to dissemination. PCI supports Clinical and Translational Research Centers (CTRCs) and Practice-Based Research Networks (PBRNs) which provide inpatient and outpatient facilities, staff, equipment, laboratory testing, and other resources. PCI resources support research across the lifespan and in specific populations including pregnant women, newborns, children, older adults, individuals with cancer, individuals undergoing physical rehabilitation, and acutely-ill hospitalized patients. PCI research facilities are located within UPMC's Oakland-Shadyside-Lawrenceville hospitals and select UPMC regional outpatient practices.